Preparation of Nano Magnesium Oxide using Marjoram Herb and Studying Its Effectiveness on Prostate Cancer Cells
نویسندگان
1 Department of Chemistry, College of Education for Pure Sciences, University of Diyala, Iraq
2 Department of Chemistry, University of Mesopotamia, Iraq
3 Department of Chemistry, College of Education for Pure Sciences, University of Diyala, Iraq
4 Department of Chemistry, College of Education for Pure Sciences, University of Diyala, Iraq
5 Department of Economics, College of Management and Economics, Iraq
doi
10.22052/JNS.2026.01.061چکیده
In this work, MgO NPs nanoparticles were prepared using marjoram herb extract in a novel, simple and inexpensive procedure involving techniques: co-precipitation and green chemistry. The following methods were used to characterize the produced nanoparticles: XRD, FT-IR, EDX and SEM. The average particle size measured in XRD was 3.69 nm, but the average particle size in SEM was 0.203 nm. The efficacy of the synthesized MgO NPs nanoparticles was evaluated against the drug Flutamide, which is administered for the treatment of prostate cancer in Iraq using PC3 cell line. The results showed the distinct efficacy of the nanoparticles and their superiority over the drug. In addition, they were characterized by their non-cytotoxicity when measured against the drug’s toxicity on red blood cells in a cytotoxicity screening test. If the results indicated that flutamide had a cell killing value of 18.69%, 26.79%, 39.27%, 45.27%, 68.29% at 48 h, and for MgO NPs, respectively, the cell killing results were 30.18%, 39.97%, 47.73%, 60.88%, 84.9%, respectively, and the IC50 value = 70.74%.
