فهرست نشریات علمی دسترسی آزاد ایران

Nanoparticles when used along with antibiotics offer a novel strategy to combat bacterial infections. In this research, synergistic effect of Zinc Oxide (ZnO) nanoparticles with Tetracycline antibiotic in two types of bacteria including Klebsiella pneumoniae and Staphylococcus aureus were assayed. The result showed that ZnO nanoparticles and Tetracycline bound ZnO nanoparticles are both have antibacterial effect. Nevertheless, Tetracycline-conjugated ZnO NPs demonstrated strong antibacterial efficacy in comparison with ZnO NPs or Tetracyclene alone against both bacteria species tested. This increased potency indicates a possible additive effect of the nanoparticles and antibiotic. This research provides an important introduction to the ability of nanoparticles to potentiate the activity of classical antibiotics. It also highlights the possibility of synergistic effects of these combinations for surmounting resistance by bacteria. Altogether, this study opens up new ways of exploring nanoparticle-antibiotic conjugates as promising and innovative antibacterial products for clinical and industrial purposes.