فهرست نشریات علمی دسترسی آزاد ایران

Scientists are using nanotechnology in a variety of sectors, including dentistry, oncology, illness diagnosis and treatment, and the cosmetics industry, as they become more aware of the benefits of nano pharmaceuticals. This study uses the Thiazolyl blue tetrazolium bromide (MTT) cytotoxicity assay and the standard anticancer chemotherapeutic drug 5-fluorouracil (5FU) to examine the toxicological effects of magnesium oxide nanoparticles (MgO-NPs) at various concentrations (1,10,100,500, and 1000 µg/mL) on the LS-174T colorectal adenocarcinoma cell line. Zinc nitrate salts and aqueous extraction of dill extract were used to create magnesium oxide nanoparticles. Since green extraction processes use non-toxic chemicals, creating nanoparticles in environmentally benign ways is particularly interesting. One emerging area in nanotechnology is green synthesis techniques, especially those that use biological systems such as plant extracts. X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier-transform infrared spectroscopy (FT-IR) were among the methods used to characterize the synthesized MgO-NPs. This investigation demonstrated that MgO-NPs had positive therapeutic selectivity index efficacy in cell killing and inhibition (SI=2.98; IC50 = 51.26 μg/mL). It also emphasized size-dependent effects, whereby the smaller size and possible chemical lability of nanoparticles may boost cell uptake and interaction, hence resulting in increased cytotoxicity. These results have encouraging ramifications for MgO-NPs' therapeutic uses in cancer treatment.