فهرست نشریات علمی دسترسی آزاد ایران

Bioactive glass-ceramics are utilized as bone tissue replacements due to their bioactivity, compatibility, and their capacity to form a crystallized hydroxyapatite (HA) bonding layer, which closely mimics the composition and structure of the inorganic component of bone minerals. The main objective of this research is to assess the effect of adding ZrO₂ and Ag₂O on the properties of bioactive glass-ceramics based on a composition of 45 wt.% SiO₂, 24.5 wt.% Na₂O, 24.5 wt.% CaO, and 6 wt.% P₂O₅.The bioactive glass-ceramics were synthesized using traditional glass-melting techniques at 1200°C for 2 hours, followed by compression and sintering at 950°C. X-ray diffraction analysis confirmed the formation of Na₂CaSi₃O₈ and Na₂Ca₂Si₃O₉ phases in the bioactive glass-ceramic structure. Mechanical and physical testing revealed that increasing the ZrO₂ and Ag₂O content improved bending strength, compressive strength, microhardness, and density, while reducing porosity. FTIR spectroscopy confirmed the presence of Si-O-Ag and Zr-O-Si bonds in the material. The biological testing involved immersing the samples in simulated body fluid (SBF) for 21 days. Scanning electron microscopy (SEM) analysis showed the formation of apatite layers on the surface of the samples, providing evidence of their bioactivity. Overall, the results of this study indicate that partial replacement of CaO with ZrO₂ and Ag₂O in the 45S5 glass-ceramic enhances both mechanical and biological properties, suggesting that the modified glass-ceramic is well-suited for biomedical applications.