Enhancing the Performance of Lipophilic Chemotherapeutic Agent via Polymeric Nanoparticle Fabrication
نویسندگان
1 Department of Pharmaceutics, College of Pharmacy, University of Kerbala, Kerbala, Iraq
2 Department of Pharmaceutics, College of Pharmacy, University of Kerbala, Kerbala, Iraq
3 Department of Pharmaceutics, College of Pharmacy, Ahl Al Bayt University, Kerbala, Iraq
4 Department of Pharmaceutics, College of Pharmacy, Al- Esraa University, Baghdad, Iraq
5 Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
6 Department of Pharmaceutics, College of Pharmacy, University of Kerbala, Kerbala, Iraq
7 Department of Pharmaceutics, College of Pharmacy, AlMustansiriyiah University, Baghdad, Iraq
doi
10.22052/JNS.2025.04.039چکیده
Lomustine, a chemotherapeutic agent used in the treatment of brain tumors and other malignancies, is limited by its poor water solubility and systemic side effects. This study aimed to formulate and evaluate lomustine-loaded nanoparticles to enhance its solubility, stability, and controlled release profile. Nanoparticles were prepared using the nanoprecipitation method with polylactic-co-glycolic acid (PLGA) as the polymeric carrier. The formulations were evaluated for particle size, zeta potential, drug loading, entrapment efficiency, and in vitro drug release. The optimized formulation exhibited a particle size of 198.1 nm, zeta potential of -17.2 mV, and an entrapment efficiency of 74.16%. FTIR and DSC analyses confirmed the absence of drug-polymer interactions. The in vitro release study demonstrated a sustained release profile over 24 hours, suggesting the potential of the nanoparticle formulation to improve therapeutic efficacy and reduce side effects. These findings support the application of PLGA-based nanoparticles as a promising delivery system for lomustine in cancer therapy.
