Preparation and Evaluation of Slow-Release Mesoporous Silica Nanoparticles-Curcumin Implant for Prevention of Intra-Abdominal Adhesion
نویسندگان
1 Department of Pharmaceutics, College of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq
2 Student Research Committee, Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
4 Department of Epidemiology and Biostatistics, School of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran
5 Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
6 Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord University, 115, Shahrekord, Iran
7 Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
8 Department of Surgery, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
doi
10.22052/JNS.2025.04.042چکیده
In the present study, a slow-release system of mesoporous silica nanoparticles (Msn) loaded with curcumin (cur) is intended as an implant that can have a more significant effect on preventing intra-abdominal adhesion after surgery due to its longer shelf life and extended release of the drug in the intra-abdominal area. Msn were prepared and examined for physicochemical properties. Then, these prepared nanoparticles were loaded with cur. The implant was made from loaded nanoparticles and hydroxypropyl methylcellulose (HPMC) polymer by molding method. After the implant was made, its properties, such as disintegration time, thickness and swelling, surface pH, adhesion strength, and in vitro release, were evaluated. The implants (imp) were evaluated for the effect on intra-abdominal adhesion after laparotomy in the future paper. The results showed that the fabricated nanoparticles had acceptable morphological properties. Also, the fabricated implants had pH within the limits of normal tissue and suitable adhesion, swelling, and disintegration time. The highest adhesion strength was associated with imp, and the highest swelling was associated with imp/cur.
