فهرست نشریات علمی دسترسی آزاد ایران

Breast cancer accounts for 30% of new cancers in women and is known as the most common malignant cancer in women in the world. The present study focused on the antioxidant, antibacterial and anti-proliferative activities of Opuntia ficus-indica L. nano-emulsion (NE-OFI) on MCF-7 cell line and determined effect of NE-OFI in an in vivo study in breast cancer animal model. Treatment with NE-OFI (230 µg/mL) significantly upregulated pro-apoptotic genes (Bax, Caspase-3) while downregulating Bcl2 in MCF-7 cells. It also induced oxidative stress, increasing ROS and reducing antioxidant enzymes. Antibacterial assays showed MICs of 80 µg/mL (E. coli) and 160 µg/mL (P. aeruginosa). In vivo, NE-OFI (400 mg/kg) reduced tumor size and enhanced apoptosis in breast cancer models. Histopathological analysis confirmed increased tumor cell death. These findings suggest NE-OFI’s potential as a natural therapeutic agent against breast cancer, combining antioxidant properties with antibacterial effects against Gram-positive and Gram-negative bacteria.