Preparation of 2,3-Disubstituted Quinazoline-4(3H)-One Derivatives in the Presence of CuO/Graphene Oxide as an Effective Catalyst
نویسندگان
1 Department of Chemistry, Qom Branch, Islamic Azad University, Qom, Iran
2 Department of Chemistry, Qom Branch, Islamic Azad University, Qom, Iran
3 Department of Chemistry, Qom Branch, Islamic Azad University, Qom, Iran
4 Department of Chemistry, Qom Branch, Islamic Azad University, Qom, Iran
doi
10.22052/JNS.2025.04.058چکیده
In this research, a series of 2,3-disubstituted quinazoline-4(3H)-one derivatives has been synthesized in high selectivity by one-pot multicomponent reaction through the reflux method. The performance of various techniques was studied comparatively on the attributes of the product and catalyst by applying different characterized tests. The copper oxide/graphene oxide composites (CuO/GO nanocomposite) were well prepared using a co-precipitation method and characterized to confirm their structure and composition. According to the obtained data, the reflux method provides a mild process, and as a result, time and energy are saved. The reaction was efficiently promoted by 20 mg of CuO/GO composite as a robust and heterogeneous nano-sized catalyst. As expected, the proposed heterogeneous nano-sized catalyst that was designed and prepared, performed well in promoting the studied products (up to 93%). High to excellent yield, saving energy and time, chemical/thermal stability, eco-friendliness, and reusability of nanocatalyst (5 runs) are several of the outstanding advantages of this research.
