فهرست نشریات علمی دسترسی آزاد ایران

The aims of study is detecting the impact antioxidant Propolis-loaded lipid nanoparticles (PLNs) in male rats. Sixty-four male mature male Wister rats (aged 90 days and weighted 148±10 g) divided four group. Group 1 were Control group drenched with distilled water for (28) days and Second group were administered Propolis extraction (PL) (10 mg\\kg\\day), third group administered with free LNPs (20mg \\ Kg) and the fourth group administered with LNPs-PL (20mg\\ kg \\day). The result of X-Ray diffraction of LNPs-PL in major peak at 28.56° in the diffract to gram has moved to a lower 2θ value. The Zeta Potential (ZP) values of all formulations prepared were measured to be negative. The result indicates that the ZP ranges between 33.7 mV to -48.7 mV with the smallest size comprising the PLNs. The PDI value in the case of LNPs- PL   were 0.265. The change in liver enzyme indicated a significant increase (P 0.05) in the expression of gene of Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and Alkaline phosphatase (ALP) in G4 group in comparison of control group (G1) 14 and 28 days later. The results also indicated that G2 group recorded a significant increment (62 C (P600.05)) after a period of 28 days compared to the same group after 14 days. Whereas, the transcript output of the Antioxidants revealed that there was a significant reduction (P Effect on Shell deformities on the gene expression of Super Oxide Dismutase (SOD1) in the G4 group than in the control group (G1), after 14 and 28 days. The results also indicated a huge reduction (P14 days as compared with G4 group after 28 days (P 0.05).