فهرست نشریات علمی دسترسی آزاد ایران

Paclitaxel, a widely used chemotherapeutic agent—particularly for breast cancer—faces limitations such as low bioavailability, rapid metabolism, degradation, and poor aqueous solubility. Known as a mitotic inhibitor, paclitaxel’s effectiveness can be enhanced through nanocarrier systems. In this study, paclitaxel was delivered using iron oxide–graphene oxide–polyethylene glycol (iron oxide–GO–PEG) nanoparticles. The structural and morphological characteristics of both the unloaded and paclitaxel-loaded iron oxide–GO–PEG nanoparticles were analyzed using Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), X-ray diffraction (XRD), Raman spectroscopy, thermogravimetric analysis (TGA), and zeta potential measurements. The cytotoxic efficacy of free paclitaxel and paclitaxel-loaded nanoparticles was evaluated in MCF-7 human breast cancer cells using the MTT assay. Results showed that paclitaxel-loaded iron oxide–GO–PEG nanoparticles exhibited significantly higher cytotoxicity compared to free paclitaxel, indicating enhanced drug delivery efficiency. These findings suggest that iron oxide–GO–PEG nanocarriers represent a promising platform for improving paclitaxel delivery and offer potential for the development of more effective breast cancer therapies.