Evaluation of the Effectiveness of Palladium (II) Complex with a New Ligand Derived from 2-Hydrazinylbenzoxazole and 2-Aminothiazole in Anticancer Activity
نویسندگان
1 Department of Chemistry, College of Education, University of AL-Qadisiyah, Iraq
2 Department of Chemistry, College of Education, University of AL-Qadisiyah, Iraq
doi
10.22052/JNS.2025.03.008چکیده
The new 2-(2-(benzoxazole-2-yl)-hydrazinildene)-2,1-diphenyl-N-(thiazole-2-yl)ethane-1-amine (BOHPTEI) ligand was prepared from the mixture of 2-mercaptobenzoxazole with hydrazine dissolved in absolute ethanol to form compound-A, while the ligand was obtained in its final form from the reaction of compound-A with each of benzil and 2-aminothiazole. The Pd (II) complex was prepared through the reaction between palladium chloride and BOHPTEI ligand. The structures of the prepared ligand and its complex has been characterized using a variety of spectroscopic techniques such as FT-IR, UV-Visible, and 1H-NMR, FE-SEM, atomic absorption, molar conductivity, elemental microanalysis, magnetic susceptibility measurements, and melting points. The azomethine of the benzoxazole and thiazole rings, as well as the nitrogen atoms of the azomethine groups of the schiff base, were found to coordinate with the metal ion in the FTIR spectrum of the ligand. Depending on the UV-Visible and magnetic sensitivity measurements, the complex had a square planar geometry. Further measurements have proven that the Pd (II) complex can be used in an anti-cancer activity.
