Synthesis, Characterization, and Anticancer Evaluation of a Novel Imine-Oxime Ligand Derived from 2-Hydrazinyl Benzothiazole and Its Palladium(II) Complex
نویسندگان
1 Department of Chemistry, College of Education, University of Al-Qadisiyah, Diwaniyah, Iraq
2 Department of Chemistry, College of Education, University of Al-Qadisiyah, Diwaniyah, Iraq
doi
10.22052/JNS.2025.03.014چکیده
The nano ligand, (2E,3E)-3-((4-((E)-1-(2-(benzo[d]thiazol-2-yl) hydrazineylidene) ethyl)phenyl) imino) butan-2-one oxime (BTHEPIBO), was synthesized in three steps. The first stage produced 2-hydrazineylbenzothiazole by reacting 2-mercaptobenzothiazole with hydrazine hydrate in ethanol. Second, a few drops of glacial acetic acid catalyzed the reaction of 4-aminoacetophenone with diacetyl monoxime in ethanol. In the last step, the two intermediate products formed nano BTHEPIBO ligand. The reaction with palladium (II) chloride produced a palladium (II) complex of this nano ligand. FT-IR, 1H-NMR, UV-Vis, melting point determination, FESEM, XRD, and magnetic susceptibility measurements were used to determine the chemical structures of the nano ligand and its palladium complex. The synthesized nano ligand and palladium (II) complex were tested for their impact on MCF-7 breast cancer cell proliferation. The nano ligand and its combination inhibited cancer cell multiplication, suggesting possible use in cancer treatment. This paper shows the effective synthesis and complete characterization of a novel nano ligand and its complex, as well as their intriguing biological properties, paving the path for medicinal chemistry research.
