Synthesis, Characterization, and Biological Evaluation of Nano Schiff Base Derivatives and Their Conversion into Oxazepine and Imidazoline Derivatives: A Comprehensive Study
نویسندگان
1 Department of Chemistry, College of Education, University of Al-Qadisiyah, Diwaniyah, Iraq
2 Department of Chemistry, College of Education, University of Al-Qadisiyah, Diwaniyah, Iraq
doi
10.22052/JNS.2025.03.013چکیده
This work synthesizes, characterizes, and biologically evaluates nano Schiff-base compounds and their transition into oxazepine and imidazoline derivatives. Under reflux conditions, aldehyde and ketone derivatives reacted with amine derivatives in absolute ethanol and glacial acetic acid. The reactions were monitored using thin-layer chromatography (TLC), and the products were recrystallized from 100% ethanol. The structural integrity of resulting compounds was confirmed using FT-IR, 1H-NMR and 13C-NMR spectroscopy. FT-IR analysis showed functional group modifications such NH2 and C=N stretch band disappearance and C=O stretch band emergence. 1H-NMR and 13C-NMR studies gave in-depth insights into proton and carbon environments, enabling successful synthesis of target molecules. Synthesized derivatives were tested for anticancer activity using the MTT assay against MCF-7 breast cancer cells and WRL-68 normal liver cells. The results showed a dose-dependent suppression of cell proliferation, with greater derivative concentrations harmful to MCF-7 cells but less hazardous to WRL-68 cells. These half-maximal inhibitory concentration (IC50) values for compounds showed their potential as anticancer agents. XRD and FESEM analyses revealed the derivatives’ crystalline structure and surface morphology. FESEM images showed particle size and surface shape, reflecting the compounds’ production circumstances and probable uses. XRD patterns showed variable crystallinity.
