فهرست نشریات علمی دسترسی آزاد ایران

This study determined the surface morphological, structural, and biological properties of the green synthesized Ce0.5Nd0.5O1.75 nanostructures with aim of exploration of its potential as a novel therapeutic agent for cancer treatment. Observations showed a well-designed quasi-spherical sample with an average particle size of 38.60 nm. XRD pattern revealed highly crystalline in nature with a cubic crystal structure and a crystallite size of 9.25 nm. EDX analysis showed the elemental composition with atomic percentages of 41.17% for O, 31.69% for Nd, and 27.14% for Ce. Raman spectrum demonstrated a prominent peak at 460 cm⁻1 and a secondary peak at 600 cm⁻1, indicating the F2g symmetric breathing mode and presence of oxygen vacancies. The biological properties of the samples were studied using the MTT assay to evaluate cytotoxicity against A549 lung cancer cells. Six concentrations (6.25–200 μg/mL) were tested, with significant reductions in cell viability observed at concentrations ≥12.5 μg/mL. The Ce0.5Nd0.5O1.75 nanostructures exhibited a dose-dependent cytotoxic profile with an IC50 of approximately 100 μg/mL. Compared to standard chemotherapies like cisplatin and pemetrexed, which induced almost complete cell death at higher doses, the Ce0.5Nd0.5O1.75 nanostructures showed a more gradual and potentially less toxic impact on cell viability. Fluorescence imaging corroborated these findings, showing intense fluorescence in control cells and reduced fluorescence in treated cells, indicative of metabolic disruption. Three different treatment conditions demonstrated the nanostructure’s potential for targeted therapy with lower toxicity. Overall, Ce0.5Nd0.5O1.75 offers promising prospects as a cancer therapeutic agent due to its unique structural attributes and controlled biological interactions.