فهرست نشریات علمی دسترسی آزاد ایران

Spironolactone is a synthesized steroid potassium-sparing diuretic utilized in the management of heart failure and hypertension. Due to inadequate water solubility, spironolactone demonstrates low oral bioavailability. Thus, inclusion of spironolactone into a nano micelle system has been proposed to improve the solubility and dissolution rate. Nanomicelles were prepared via the solvent evaporation technique, utilizing different polymer types and relative ratios. The selected formulation was evaluated through FTIR, PXRD, DSC and TEM. FTIR and PXRD analyses confirmed the absence of chemical interaction between spironolactone and soluplus, while PXRD and DSC results indicated a transition of the crystalline spironolactone to an amorphous state. Polymeric nanomicelle has emerged as promising pharmaceutical drug carriers that improve the solubility and dissolution rate of spironolactone.