فهرست نشریات علمی دسترسی آزاد ایران

Methodology: The present research examines the anti-diabetic efficacy of gold nanoparticles (AuNPs) in a model of diabetes induced by streptozotocin (STZ) in mice. A group of 50 Swiss albino mice underwent a treatment protocol lasting 30 days with AuNPs administered at different concentrations. Histological assessments of liver and pancreatic tissues were performed, and the structural alterations resulting from AuNP treatment were evaluated through various analytical techniques, including X-ray diffraction (XRD), UV-visible spectroscopy, Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and transmission electron microscopy (TEM).Results: However, at high concentrations, AuNPs elicited pathological changes that involved enhanced oxidative stress, inflammation, and evidence of apoptosis in both hepatic and pancreatic tissues. At administered doses, however, AuNPs induced pancreatic β-cell proliferation as well as enhanced organization and tissue remodeling within the pancreas. These results support AuNPs for possible pharmaceutical use. XRD and UV-visible spectroscopy confirmed the FCC structure of pea-shaped AuNPs both before and after functionalization. The strong affinity between AuNPs, TB O dye, and lemon extract was revealed from FTIR analysis, hence increasing the stability and usability of the nanoparticles.Conclusion: Gold nanoparticles, when administered at suitable concentrations, exhibit potential as a dual-purpose agent in the management of diabetes, providing therapeutic advantages through the enhancement of β-cell regeneration and the restoration of tissue integrity. Nonetheless, at elevated toxic levels, they can cause cellular harm. Additional research is required to accurately assess their therapeutic index and to comprehensively grasp their prospective clinical applications.