Synergistic Effects of Carbon Nanotubes with Methotrexate for Osteosarcoma: A Review
نویسندگان
1 Department of Chemistry and Biology, Peoples’ Friendship University named after Academician A. Kuatbekov, Shymkent, Republic of Kazakhstan
2 Department of physics, College of Education for Pure Sciences, University Of Anbar, Iraq
3 Department of Dentistry, Al-Manara College For Medical Sciences, Maysan, Iraq
4 College of Pharmacy, Ahl Al bayt University, Kerbala, Iraq
5 Al-Hadi University College, Baghdad, Iraq
6 College of Health and Medical Technologies, National University of Science and Technology, Dhi Qar, Iraq
7 Department of Medical Laboratories Technology, Al-Nisour University College, Baghdad, Iraq
8 Mazaya University College, Iraq
9 O. Zhanibekov South Kazakhstan Pedagogical University, Shymken, Republic of Kazakhstan
doi
10.22052/JNS.2025.02.029چکیده
Osteosarcoma, a highly aggressive primary bone cancer, poses significant therapeutic challenges, particularly due to multidrug resistance and limited efficacy of conventional chemotherapy. Methotrexate (MTX), a widely used antineoplastic agent, suffers from poor bioavailability and systemic toxicity, necessitating the development of advanced drug delivery approaches. In this study, carbon nanotubes (CNTs) are explored as nanocarriers to enhance MTX delivery, aiming to improve therapeutic outcomes. CNTs offer unique physicochemical properties, including high surface area, functionalization potential, and efficient cellular uptake, which can facilitate targeted drug transport and sustained release. The synergistic interaction between CNTs and MTX enhances drug bioavailability, minimizes off-target effects, and improves cytotoxic efficacy against osteosarcoma cells. Experimental findings suggest that CNT-based MTX delivery can overcome resistance mechanisms and significantly improve therapeutic precision. This paper reviewed the current advancements in CNT-mediated drug delivery systems for osteosarcoma, summarizing key experimental findings their implications in overcoming therapeutic challenges.
