Synergistic Effects of Hydrogel Nanoparticles and Docetaxel for Prostate Cancer: A Review
نویسندگان
1 Department of Pharmacy, Al-Turath University, Iraq
2 Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq
3 Al-Hadi University College, Baghdad, Iraq
4 Warka University College, Iraq
5 Mamun University, Uzbekistan
6 Department of Social and Economic Sciences, Kokand University, Andijan Branch, Andijan, Uzbekistan
7 Department of Biochemistry, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
8 Department of Pharmacology, College of Pharmacy, University of Al-Ameed, Iraq
9 College of Health and Medical Technologies, National University of Science and Technology, Dhi Qar, Iraq
10 Mazaya University College, Iraq
11 Bukhara State Medical Institute named after Abu Ali Ibn Sina, Bukhara, Uzbekistan
12 Department of Pedagogy and Psychology, Kokand University, Fergana, Uzbekista
13 Urgench State University, Urganch, Khorezm, Uzbekistan
doi
10.22052/JNS.2025.02.034چکیده
Prostate cancer remains one of the most prevalent malignancies affecting men worldwide, necessitating continuous advancements in therapeutic strategies to improve clinical outcomes. Docetaxel, a microtubule-stabilizing chemotherapeutic agent, has demonstrated significant efficacy in managing metastatic castration-resistant prostate cancer. However, its clinical utility is frequently compromised by dose-dependent toxicity, suboptimal bioavailability, and the emergence of drug resistance. Nanotechnology-based drug delivery systems have gained attention for their ability to enhance therapeutic precision, improve drug solubility, and reduce systemic side effects. Hydrogel nanoparticles offer a promising platform for encapsulating docetaxel, providing controlled and sustained drug release, improved tumor selectivity, and enhanced intracellular drug accumulation. This review examines the synergistic potential of hydrogel nanoparticles and docetaxel in prostate cancer therapy, highlighting mechanistic insights into improved drug delivery efficiency, apoptotic induction, and resistance mitigation. By integrating hydrogel nanoparticle-based formulations, the therapeutic index of docetaxel can be optimized, contributing to more effective and personalized prostate cancer treatment approaches.
