فهرست نشریات علمی دسترسی آزاد ایران

Anemia is a common difficulty in chronic kidney disease (CKD) and promotes morbidity and mortality and lowers the quality of life. Most patients get oral or intravenous iron supplementation and erythropoiesis-stimulating medications. Therapy aims to improve renal function and red blood cell production. For chronic kidney disease anemia, erythropoiesis-stimulating medications and iron supplements are recommended. Oxides (hematite–α-Fe2O3) nanoparticles were synthesized by an eco-friendly method using basil leaf extract. Calcitriol was loaded onto the surface of iron oxide nanoparticles by the physical adsorption process. Then, rats with anemia associated with chronic kidney disease caused by adenine orally (100 mg/kg) for 60 days, were treated by calcitriol (0.16 mg/kg). Fe2O3NPs (200 mg/kg) and Fe2O3 NPs loaded Calcitriol, for 28 days. The albino rats were divided into five groups: control, G1 infected with CKD without treatment, G2 treated with calcitriol only, G3 treated with Fe2O3NPS only, and G4 treated with calcitriol loaded on Fe2O3NPs. The results showed a significant increase in serum levels (Hb, folate, B12, TIBC, and UIBC), and no significant difference appeared in serum ferritin and iron levels. Iron oxide nanoparticles can effectively treat anemia, and loading calcitriol onto iron oxide increases its effectiveness.