Recent Updates on Chemotherapy of Pt Complexes and Pt Nano-Composites for Breast Cancer Therapy: A Mini-Review
نویسندگان
1 Department of Fruits and Vegetables, Urganch State University, Uzbekistan
2 Department of Optics, College of Health and Medical Technology, Sawa University, Almuthana, Iraq
3 College of Pharmacy, National University of Science and Technology, Dhi Qar, Iraq
4 Mazaya University College, Iraq
5 Department of Hospital and Faculty Surgery, Fergana Medical Institute of Public Health, Uzbekistan
6 Department of Pharmacology, College of Pharmacy, University of Al-Ameed, Karbala, Iraq
7 College of Pharmacy, Ahl Al Bayt University, Kerbala, Iraq
8 Al-Manara College for Medical Sciences, Amarah, Iraq
9 Department of Medical Laboratories Technology, Al-Nisour University College, Baghdad, Iraq
10 Department Clinic Pharmacology, Bukhara State Medical Institute, Uzbekistan
11 International School of Finance Technology and Science, Uzbekistan
12 International School of Finance Technology and Science, Uzbekistan
13 Uzbekistan-Finland Pedagogical Institute, Uzbekistan
doi
10.22052/JNS.2025.01.018چکیده
Breast cancer continues to be one of the most widespread cancers globally, underscoring the need for the ongoing development of treatment strategies to enhance patient outcomes. This review examines the significance of platinum (Pt) complexes and platinum nanocomposites in the chemotherapy of breast cancer, emphasizing their distinct mechanisms of action and potential to improve treatment effectiveness. Conventional chemotherapeutic agents frequently encounter issues such as systemic toxicity and the emergence of drug resistance, challenges that platinum-based compounds, particularly cisplatin and its analogs, seek to mitigate. Recent progress in nanotechnology has facilitated the creation of targeted delivery systems that enhance the bioavailability and localization of platinum compounds at tumor sites, thereby minimizing off-target effects. This review evaluates various studies that investigate the synthesis, characterization, and anticancer mechanisms of platinum nanoparticles (PtNPs) and their composites, including their interactions with breast cancer cell lines and their potential role as radiosensitizers. Furthermore, we explore the combination of platinum-based therapies with immune checkpoint inhibitors and other innovative treatments to address resistance mechanisms, especially in aggressive subtypes such as triple-negative breast cancer (TNBC). The role of personalized medicine, informed by genetic and molecular profiling of tumors, is also discussed in relation to the selection of suitable platinum therapies. By clarifying the current state and future prospects of platinum complexes in breast cancer treatment, this review aims to contribute to ongoing research initiatives and stimulate novel strategies to enhance therapeutic effectiveness and improve patient quality of life.
