فهرست نشریات علمی دسترسی آزاد ایران

Silybum marianum, commonly known as milk thistle, is a botanical species that has been utilized in various traditional medicinal practices and is regarded as a promising ancient herb. The objective of the current investigation was to synthesize and characterize MnO nanoparticles utilizing milk thistle seed extract. The production of MnO2 nanoparticles was accomplished through the combination of manganese acetate and a heated aqueous extract derived from dry milk thistle seeds. The MnO nanoparticles that were produced underwent characterization through various analytical techniques including UV-Visible spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Energy-dispersive X-ray analysis (EDS), and Field emission scanning electron microscopy (FESEM) analysis. According to the findings of the investigations mentioned above, the produced MnO nanoparticles are spherical and 55 nm in size. The present study aimed to investigate the potential anticancer properties of Mn NPs and milk thistle seed extract against human breast cancer cells (MDA-MB-468). The half-maximal inhibitory concentrations (IC50) were determined to be 32.4𝜇g/mL after 48 hours of incubation. The Mn NP nanoparticles that have been synthesized exhibit noteworthy anti-cancer properties. The present study introduces a new environmentally sustainable approach for the synthesis of nanomaterials that possess enhanced or additional therapeutic properties originating from herbal sources.  The biocompatibility and non-toxic characteristics exhibited by Mn NPs make them a suitable choice for employment in the field of biomedical applications. Despite this, it has been observed that Mn nanoparticles exhibit cytotoxic properties against cancerous cells, rendering them particularly advantageous for employment in the fields of cancer diagnosis and treatment.