فهرست نشریات علمی دسترسی آزاد ایران

Background: Tannic acid plays a significant role in modifying silver nanoparticles due to its unique properties and functionalities. Objective(s) : In this work, demonstrate the tannic acid modified silver nanoparticles exhibit different cytotoxicity compared to other silver nanoparticles due to the presence of the tannic acid coating. The tannic acid modification with silver nanoparticles can decrease their ability to inhibit the proliferation of MDCK cells line. Tannic acid itself has antioxidant properties and can scavenge free radicals, which may help mitigate the cytotoxic effects of silver nanoparticles. Materials and Methods: A green biosynthesis was used to prepare successful product and establish a tannic acid and silver nanoparticles (TA-AgNPs). TA-AgNPs was prepared in several concentrations (3.1, 6.25, 12.5, 25, 50) μg/mL and evaluated for cytotoxicity effect in vitro normal MDCK cell line. on the surface of silver nanoparticles tannic acid was effectively modified and characterized via UV Visible Spectroscopy, Fourier transform infrared (FTIR) spectroscopy, AFM, XRD, SEM and TEM. Results: The observations with SEM indicated that produced TA-AgNPs had a spherical shape with a mean particle size of 13.55±5.9 nm. The cytotoxic effect and The anti-proliferative activity of TA-AgNPs treated MDCK cells showed the TA-AgNPs have less cytotoxicity and high bioavailability rate (90.66±0.7212) than AgNPs (90.65±0.8864)in the same concentration (50 μg/mL). Conclusion: This study revealed that tannic acid modified silver nanoparticles have a highly effective metal nanoparticles with promising new applications. Because of its significant unique properties, tannic acid may be referred to as the cross-linker in the future.