فهرست نشریات علمی دسترسی آزاد ایران

In this study, CuCr2O4 nanoparticles were prepared by utilizing rosemary leaf extract in a novel, simple, and inexpensive procedure that incorporated three techniques: co-precipitation, ultrasound, and green chemistry. The following methods were used to characterize the produced nanoparticles: XRD, FT-IR, EDX, SEM, and Zeta Potential. The average particle size measured in the XRD was 40.65nm. Still, the energy dispersive X-ray spectroscopy analysis showed that the weight percentages of the CuCr2O4 nanoparticles prepared by the green method are Cr 47.8%, Cu 42.7%, and O 9.4%. The Zeta Potential ZP was 5.6 mV. The average particle size in the SEM was 41.51 nm. The efficacy of the prepared nanoparticles was studied on the MCF-7 breast cancer cell line and compared with the drug Nolvadex-D used in the treatment of breast cancer in Iraq. The results demonstrated the nanoparticles’ outstanding efficacy and superiority over the medication. In addition, they were distinguished by their lack of cytotoxicity when measured against the drug’s toxicity on red blood cells in the toxicity screening test. If the results indicated that the drug Nolvadex-D had a cell killing value of (12.29%, 25.29%, 41.01%, and 54.59%) respectively at 24 hours, as well as for CuCr2O4, respectively at 24 hours, the cell killing results were (28.96%, 60.55%, 43.56%, and 64.01%) as well value IC50 (247.7ppm).