فهرست نشریات علمی دسترسی آزاد ایران

Pathogenic microorganisms that are resistant to antibiotics have made it necessary to look for new antimicrobials. Nowadays, employing nanoparticles as therapeutic agents may be novel and promising. Cadmium Oxide (CdO) nanoparticles were found to have antibacterial efficacy against bacteria that tested negative for the gram stain, such as Pseudomonas aeruginosa, Salmonella typhi, Morganella morganii, Klebsiella pneumoniae, Proteus vulgaris, and Serratia spp. They were also shown to have antimicrobial activity against bacteria that were positive for the gram stain, including Streptococcus, Staphylococcus aureus (ATCC 25923) measured between (10.0 to 18.5) mm, while antifungal agents were evaluated on Candida albicans and Candida kruzi with inhibition zones of 10.0 and 10.5 mm. The well diffusion approach was used to measure the nanoparticles’ activity. The evaluated CdO nanoparticles had a concentration range of 100 mg/ml, and the activity was assessed by measuring the zone of inhibition. The results of the qualitative test included the determination of the MIC and MBC values. In the MIC range of 0.078-0.52mg/ml, CdO nanoparticles demonstrated good efficacy. Staphylococcus aureus demonstrated the maximum activity (MIC 0.078 mg/ ml), whereas E. coli displayed low susceptibility (MIC 0.83 mg/ ml). The cadmium oxide nanoparticles were studied using scanning electron microscopy with EDAX analysis and X-ray diffraction.