فهرست نشریات علمی دسترسی آزاد ایران

This study focused on the synthesis of a variety of Schiff bases and their corresponding tetrazole derivatives. The Schiff bases were prepared by reacting quinaldic acid hydrazide with different aromatic aldehydes, followed by cyclization with sodium azide to form tetrazoles. The structures of the synthesized compounds were confirmed using spectroscopic techniques including FT-IR, XRD, FESEM, and ¹H and ¹³C-NMR. Thin-layer chromatography (TLC) was utilized to verify the purity of the compounds. The biological properties of the synthesized compounds were investigated against two bacterial species (Staphylococcus epidermidis and Escherichia coli) and a fungal species (Candida albicans). Furthermore, blind molecular docking studies were performed to identify potential binding sites of these compounds within bacterial and fungal receptors. The antioxidant properties of several compounds were also examined, demonstrating antioxidant activity in some of the selected compounds. The results indicated that the synthesized tetrazole derivatives have significant biological and antioxidant activities, making them potential candidates for further pharmaceutical development.