Exploiting pH-Sensitive Polymer Micelles Nanoparticles for Paclitaxel Delivery and Tumor Suppression: Advanced Targeted Cancer Therapy
نویسندگان
1 College of Pharmacy, Ahl Al Bayt University, Kerbala, Iraq
2 AlSafwa University College, Iraq
3 Mazaya University College, Iraq
4 Al-Zahrawi University College, Karbala, Iraq
5 Department Clinic Pharmacology, Bukhara State Medical Institute, Uzbekistan
6 International School of Finance Technology and Science, Uzbekistan
7 Department of Polymer Chemistry and Chemical Technology, Samarkand state university, Samarkand, Uzbekistan
8 Department of Pharmaceutics, College of Pharmacy, University of Al-Ameed, Karbala, Iraq
9 Department of sciences, Al-Manara College for Medical Sciences, Maysan, Iraq
10 Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq
11 Department of Fruits and Vegetables, Urganch State University, Uzbekistan
12 Department of Neurology and Psychiatry, Fergana Medical Institute of Public Health, Fergana, Uzbekistan
13 Samarkand State Veterinary Medicine, Nukus branch, Livestock and Biotechnologies, Uzbekistan
doi
10.22052/JNS.2024.03.022چکیده
Targeted cancer therapy aims to enhance the efficacy and safety of treatments by directing therapeutic agents specifically to tumor sites. This review discusses the potential of pH-sensitive polymer micelles as carriers for paclitaxel, a chemotherapeutic agent, in advanced cancer treatment. By exploiting the unique tumor microenvironment, these nanoparticles can effectively release paclitaxel in a controlled manner, enhancing drug accumulation in cancer cells while minimizing systemic toxicity. The combination of paclitaxel with pH-sensitive polymer micelles presents a promising strategy for tumor suppression, potentially overcoming the limitations of conventional chemotherapy. The review highlights recent advancements, mechanisms of action, and clinical implications of using pH-sensitive polymer micelles for paclitaxel delivery.
