Investigation of Copper/Sodium Alendronate Drug Doped TiO2 Nanoparticle Array on Ti as a Hybrid Material for Implant Application
نویسندگان
1 Department of Chemistry, Faculty of Science, Yazd University, Yazd 8915818411, Iran
2 Department of Chemistry, Faculty of Science, Yazd University, Yazd 8915818411, Iran
3 Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran
4 Department of Cell and Molecular Biology, Faculty of Chemistry, University of Kashan, Kashan, Iran
5 Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
6 Department of Chemistry, Faculty of Science, Yazd University, Yazd 8915818411, Iran
doi
10.22052/JNS.2024.02.007چکیده
In this study, copper and chitosan were used because of their excellent antimicrobial properties. Electrochemical impedance tests show that an HA/Cu/Drug/chitosan (Chit) coating has a polarization resistance of 300,000 Ω because the copper coating on the titanium dioxide nanoparticle (TNP) increases corrosion resistance. A potentiodynamic polarization test shows that the current of corrosion of the HA/Cu/Drug/chitosan sample is 2.1719 × 10−6 A. The antibacterial activity of the HA/Drug, HA/Drug/Chit, and HA/Cu/Drug/Chit coatings was evaluated in vitro against Staphylococcus aureus ATCC 29737, and it is found that the HA/Cu/Drug/Chit coating presents high antibacterial activity due to the presence of copper and chitosan. Its optical density is 0.78, which is lower than that of all the other samples. Cell viability is highest for the TNP samples containing chitosan. Regarding the TNP sample containing HA/Drug (99.4%), it is observed that the percentage of cell viability is higher than that of the TNP sample containing HA/Cu/Drug (97.54%) due to the toxicity of copper. This study shows that the modification of the titanium implants can be used to control drug release and enhance corrosion resistance, antibacterial properties, and cell viability.
