Synthesis, Spectroscopic Characterization and Biological Studies as an Anticancer of a Novel Schiff Base Ligand (LH) and Its Palladium (II) Complex Derived from Thiazole and Salicylaldehyde
نویسندگان
1 Department of Chemistry, College of Education, University of Al-Qadisiyah, Diwaniyah, Iraq
2 Department of Chemistry, College of Education, University of Al-Qadisiyah, Diwaniyah, Iraq
3 Department of Chemistry, College of Education, University of Al-Qadisiyah, Diwaniyah, Iraq
4 Ministry of Education General Directorate of Al-Qadisiyah Education, Diwaniyah, Iraq
5 Department of Chemistry, College of Education, University of Al-Qadisiyah, Diwaniyah, Iraq
doi
10.22052/JNS.2024.02.009چکیده
A distinct approach in this study was the synthesis of a novel nano heterocyclic Schiff base ligand (LH) by the reaction of 1, 2-diphenyl-2-(thiazol-2-ylimino) ethan-1-one with 1-(4-((2-hydroxybenzylidene) amino) phenyl) ethenone and 4,4’-methylene dianiline. A chelate complex is formed when Schiff base ligand (LH) reacts with palladium (Pd (II)) ions. Synthesized ligand and its complex were characterized by different characterization techniques including UV-Visible, Fourier-transform infrared (FTIR) spectroscopy, proton nuclear magnetic resonance (1H-NMR), molar conductivity, melting point, atomic absorption, magnetic susceptibility, CHNS elemental analysis, Field emission scanning electron microscopy (FESEM) and X-ray diffraction (XRD). Results of the characterization study suggested that the Pd (II) complex have a square-planar geometry with metal to ligand ratio of 1:1. For exploring the potential of the synthesized complex against a breast cancer cell line (MCF-7) and normal HEK cell line (for comparison study), the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) cytotoxicity assay was employed for evaluating the anticancer activities of the synthesized materials. Overall, the results of the study revealed that synthesized novel nano Schiff base ligand (LH) and its Pd (II) complex possess the remarkable anticancer properties and can be used as an anti-cancer drug in the field of medicine.
