Synthesis, Characterization, and In Vivo Evaluation of Polyurethane-based Scaffolds Containing Graphene Oxide and Icariin for Bone Tissue Engineering
نویسندگان
1 Department of Chemistry, College of Education for Pure Science, University of Bsarah, Basra, Iraq
2 Department of Chemistry, College of Education for Pure Science, University of Bsarah, Basra, Iraq
doi
10.22052/JNS.2024.02.023چکیده
In this work, porous scaffolds are based on polyurethane, with graphene oxide (GO) and Iiracin nanospheres. We fabricated scaffolds using Toluene diisocyanate and polyelectrolyte, incorporating graphene oxide and Icariin-loaded nanospheres, scaffolds were thoroughly characterized using various analytical techniques, including FTIR, XRD, H-NMR, 13C NMR, and SEM. Decomposition patterns were evaluated in oxidizing and enzymatic settings, demonstrating steady disintegration across multiple weeks. The results of the in vivo analysis provided compelling evidence of their therapeutic potential, with both scaffold variants showing good biocompatibility in rabbit models, the TDI/GO/I scaffold particularly excelled, demonstrating enhanced bone regeneration and stable hematological profiles over the four-week implantation period, radiographic analysis revealed progressive bone formation, with significant defect closure observed by week three, while blood parameters remained within normal ranges throughout the study.
