A Dual-Function Approach for Cancer Therapy and Environmental Remediation with Advanced Photocatalytic, Antibacterial, and Antioxidant Properties: Gold-Doped Zinc Oxide Nanoparticles

نویسندگان

1 Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

2 School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom

3 Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran

doi
10.22052/JNS.2024.01.012
چکیده

In recent years, the removal of industrial wastewater has emerged as a significant environmental challenge. In this study, we aimed to introduce a nanoparticle with not only catalytic removal properties but also biological capabilities in anticancer, antibacterial, and antioxidant applications. Gold-doped zinc oxide nanoparticles were synthesized in the presence of sambucus nigra extract. The synthesized nanoparticles were characterized using SEM, EDS, TEM, FT-IR, and XRD. The results revealed that the nanoparticles exhibited high purity and a spherical morphology. The photocatalytic degradation of methyl orange by the ZnO-Au nanoparticles demonstrated their high degradation efficiency under both UV and visible light conditions. Anticancer activity assays indicated that the ZnO-Au nanoparticles showed significant effectiveness against AGS and MCF-7 cancer cell lines. Furthermore, the ZnO-Au nanoparticles exhibited strong antibacterial activity against both Gram-positive and Gram-negative bacteria, with a more pronounced effect observed against Gram-negative bacteria. Additionally, the antioxidant activity of the synthesized nanoparticles showed an increase in DPPH inhibition percentage with higher nanoparticle doses. Overall, our results suggest that the synthesized nanoparticles possess unique capabilities in both environmental and biological applications.