Adsorption of Diclofenac Sodium (DS) Drug from Water on CMC-g-P(AAc-AAm) Nano-Hydrogel: Isotherm and Thermodynamic Study
نویسندگان
1 Pharmaceutical chemistry department, college of pharmacy, University of Al-Qadisiyah, Diwaniyah, Iraq
2 Department of Chemistry, University of Sahiwal, Sahiwal, Pakistan
3 College of pharmacy, University of Al-Qadisiyah, Diwaniyah, Iraq
4 Department of Chemistry, College of Education, University of Al-Qadisiyah, Diwaniyah, Iraq
doi
10.22052/JNS.2024.01.024چکیده
This study deals with adsorption of a common non-steroidal anti-inflammatory drug (NSAID) i.e., diclofenac sodium (DS) using a carboxymethyl cellulose-g-poly (acrylic acid-co-acrylamide) (CMC-g-P(AAc-AAm)) nano-hydrogel. The nano-hydrogel was prepared by free-radical polymerization method and characterized by different characterization techniques including Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and X-ray Diffraction (XRD) techniques. Adsorption of DS drug was investigated at its variable concentrations and temperature values. The analysis of characterization study highlights the presence of porosity and heterogenous surface of prepared nano-hydrogel. Ionic functional groups of nano-hydrogel i.e., -O-H, -N-H and -C=O were mainly involved in adsorption process. Isotherm models i.e., Langmuir, Freundlich, and Temkin models were studied that showed the fitness of data to Freundlich model with maximum adsorption capacity (qe (mg/g)) of 1.872 mg/g. Adsorption was also studied thermodynamically that revealed the non-spontaneous and exothermic nature of the process. Overall, study suggest that the prepared nano-hydrogel has the potential to adsorb DS drug from aqueous solution with higher efficiency and removal percentage.
