Reveiw of Synergistic Cancer Therapy: Combining Betulinic Acid and Gold Nanoparticles for Improved Efficacy
نویسندگان
1 Department of Public Health, Healthcare Management, Bukhara State Medical Institute, Uzbekistan
2 College of Pharmacy, Ahl Al bayt University, Kerbala, Iraq
3 College of Pharmacy, University of Al-Ameed, Iraq
4 Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq
5 Department of Human and Animal Physiology, National University of Uzbekistan, Uzbekistan
6 Department of Fruits and Vegetables, Urganch State University, Uzbekistan
7 AlSafwa University College, Iraq
8 Al-Hadi University College, Baghdad, Iraq
9 Department of sciences, Al-Manara College for Medical Sciences, Maysan, Iraq
10 Mazaya University College, Iraq
11 Department of Neurology and Psychiatry, Fergana Medical Institute of Public Health, Uzbekistan
12 Department of Human and Animal Physiology, National University of Uzbekistan, Uzbekistan
13 University of Geological Sciences, Uzbekistan
doi
10.22052/JNS.2024.01.023چکیده
The pursuit of innovative and effective cancer treatments remains a critical area of research. This study explores the synergistic potential of combining betulinic acid, a naturally occurring triterpene with known anticancer properties, and gold nanoparticles (AuNPs), renowned for their unique physical and chemical characteristics, to enhance cancer therapy efficacy. Betulinic acid exerts its anticancer effects through mechanisms such as apoptosis induction and mitochondrial targeting. Meanwhile, gold nanoparticles, with their exceptional biocompatibility and functionalization capacity, offer significant advantages in targeted drug delivery systems. The conjugation of betulinic acid with AuNPs aims to leverage the individual strengths of each component, potentially resulting in a more potent anticancer effect. Through a series of in vitro and in vivo studies, this research investigates the combined therapeutic outcomes, cellular uptake, distribution patterns, and mechanistic insights of the betulinic acid-AuNP complex. Preliminary a promising increase in therapeutic efficacy, highlighting the potential for this combination therapy to overcome current limitations in cancer treatment. This article provides a comprehensive overview of the properties of betulinic acid and gold nanoparticles, the rationale for their combination, and the results of preclinical and clinical studies. Furthermore, future perspectives on advancements in nanotechnology and the integration of combination therapies are discussed, emphasizing the need for continued research and development in this promising field of cancer therapy.
