Review of Advancements in Liver Cancer Treatment: The Role of Artemisinin-Loaded Lipid Nanoparticles
نویسندگان
1 College of Pharmacy, Ahl Al Bayt University, Kerbala, Iraq
2 Department of Sciences, Al-Manara College For Medical Sciences, Maysan, Iraq
3 Al-Hadi University College, Baghdad, Iraq
4 AlSafwa University College, Karbala, Iraq
5 Department of Medical Laboratories Technology, Al-Nisour University college, Nisour Seq. Karkh, Baghdad, Iraq
6 Bukhara State Medical Institute, Uzbekistan
7 Department of Philosophy and National Thought, Samarkand State University, Samarkand, Uzbekistan
8 Surgery of Samarkand State Medical University., Doctor of Philosophy (Ph.D) Medical Sciences, Uzbekistan
9 Department of Pharmaceutics, College of Pharmacy, University of Al-Ameed, Karbala, Iraq
10 College of Science, Department of Forensic Sciences, National University of Science and Technology, Dhi Qar, Iraq
11 Department of Physics and Chemistry, Tashkent Institute of Irrigation and Agricultural Mechanization Engineers, National Research University, Tashkent, Uzbekistan
12 Western Caspian University, Scientific researcher, Baku, Azerbaijan
13 Department of Philosophy and National Thought, Samarkand State University, Samarkand, Uzbekistan
doi
10.22052/JNS.2024.01.022چکیده
Liver cancer, often hepatocellular carcinoma (HCC), is a leading cause of cancer-related deaths worldwide. conventional therapies, such as surgical treatment, radiation, and chemotherapy, regularly fall short because of systemic toxicity, drug resistance, and limited efficacy. Artemisinin, a well-known antimalarial drug, has validated huge anticancer homes. latest advancements in nanotechnology have facilitated the improvement of lipid nanoparticles as efficient drug transport systems, improving the therapeutic capability of artemisinin in liver cancer remedy. This review ambitions to provide a comprehensive evaluate of the advancements in liver cancer remedy, focusing on the position of artemisinin-loaded lipid nanoparticles. It explores the mechanisms of motion of artemisinin, the advantages of lipid nanoparticles in drug delivery, and the synergistic consequences observed in preclinical and medical studies. The review also discusses the modern challenges and future perspectives in leveraging this innovative approach for effective liver cancer therapy. This paper highlights Artemisinin-loaded lipid nanoparticles constitute a promising method for liver cancer treatment. by exploiting the particular properties of each artemisinin and lipid nanoparticles, this approach offers superior tumor targeting, improved drug bioavailability, and reduced systemic toxicity. persisted studies and medical validation are critical to absolutely understand the ability of this novel healing strategy, doubtlessly remodeling the panorama of liver cancer treatment and enhancing patient effects.
