Targeted Cancer Therapy: Leveraging Dual pH-Sensitive Polymers Nanoparticles for Doxorubicin Delivery and Tumor Suppression: A Review
نویسندگان
1 Shymkent university, Mukhtar Auezov South Kazakhstan University, Shymkent, Republic of Kazakhstan
2 Department of Theory of the Russian Language and Literature, Kokand State Pedagogical Institute, Uzbekistan
3 Faculty of Agriculture, Fergana State University, Uzbekistan
4 Department of Oncology, Center for the Development of Professional Qualifications of Medical Workers, Tashkent, Uzbekistan
5 Department Clinic Pharmacology, Bukhara State Medical Institute, Uzbekistan
6 Department of Agronomy, Navoi State Mining and Technological University, Navoi, Uzbekistan
7 Andijan State medical institute, Uzbekistan
8 Faculty of Uzbek and Russian Philology, Kokand State Pedagogical Institute, Uzbekistan
9 Astana International University, Astana, Kazakhsta
10 Tashkent State Technical University, Uzbekistan
11 Department of Theory of the Russian Language and Literature, Kokand State Pedagogical Institute, Uzbekistan
12 Department of therapeutic subjects, Tashkent State Dental Institute, Uzbekistan
13 Termez State University, Termez, 190111, Uzbekistan
doi
10.22052/JNS.2024.01.021چکیده
The global burden of cancer continues to strengthen, using the want for innovative treatment methods that beautify efficacy while minimizing adverse effects. traditional chemotherapies, including the extensively used doxorubicin, face considerable demanding situations consisting of off-target toxicity, poor selectivity, and multidrug resistance (MDR). targeted drug shipping systems have emerged as a progressive solution, with dual pH-touchy polymer nanoparticles gaining significant attention. those structures exploit the acidic tumor microenvironment (TME) to enable selective and managed drug launch, improving healing consequences and lowering systemic toxicity. This overview examines the design, synthesis, and capability of dual pH-sensitive polymer systems, their mechanisms of motion, and preclinical validation. moreover, the potential of those nanoparticles to deal with the limitations of DOX remedy is highlighted, paving the way for their integration into clinical practice.
