Exploration of Some Biological Activities of Biogenic Magnesium Oxide Nanoparticles Synthesized via Heyndrickxia coagulans
نویسندگان
1 Optometry Department, AL-Najaf Technical Institute , Al-Furat Al-Awsat Technical University, Najaf, Iraq
2 Department of Health Management Technologies, AL-Najaf Technical Institute, Al-Furat Al-Awsat Technical University, Najaf, Iraq
3 Department of Biology, Faculty of science, University of Kufa, Najaf, Iraq
doi
10.22052/JNS.2024.01.025چکیده
Infections of the diabetic foot, often known as DFIs, are frequently linked to the overuse of prescribed antibiotics. This study aimed to use nanomaterials as an alternative or auxiliary approach to antibiotic therapy against P. aeruginosa isolates from DFI patients. Fifty-five bacterial isolates were identified as P. aeruginosa (27 isolates, 49%) from DFI. Bacterial isolates from the soil synthesized MgO nanoparticles, the isolate Z11, which was identified as Heyndrickxia coagulans was chosen for its efficiency in producing white precipitate. Characterization of MgO nanoparticles was conducted using Field Emission Scanning Electron Microscopy (FESEM), X-ray Diffraction (XRD), and Atomic Force Microscopy (AFM). The antibacterial activity of the synthesized nanoparticles against P. aeruginosae shows that increasing MgO nanoparticles enhanced the inhibitory activity. Additionally, MgO nanoparticles demonstrated antioxidant activity by scavenging DPPH free radicals at concentrations of 1000, 500, 250, and 125 μg/mL. Importantly, no hemolytic activity was observed for MgO nanoparticles tested with whole blood samples.
