Enhanced Tumor Targeting: Curcumin-Loaded Chitosan Nanoparticles for Precision Drug Delivery: A Review
نویسندگان
1 Department of Optics, College of Health and Medical Technology, Sawa University, Almuthana, Iraq
2 Al-Manara College for Medical Sciences, Amarah, Iraq
3 Mazaya University College, Iraq
4 Department of Medical Laboratories Technology, Al-Nisour University College, Baghdad, Iraq
5 College of Pharmacy, National University of Science and Technology, Dhi Qar, Iraq
6 Department of Pharmaceutical and Toxicological Chemistry, Kazakh National Medical University, Almaty, Kazakhstan
7 Department of Pharmaceutical and Toxicological Chemistry, Kazakh National Medical University, Almaty, Kazakhstan
8 Department of Oncology, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
9 Department of Pharmacology, College of Pharmacy, University of Al-Ameed, Karbala, Iraq
10 College of Pharmacy, Ahl Al Bayt University, Kerbala, Iraq
11 Kazakh National Medical University, Almaty, KazakhstanKazakhstan, Almaty
12 School of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
13 Department of Pharmaceutical and Toxicological Chemistry, Kazakh National Medical University, Almaty, Kazakhstan
doi
10.22052/JNS.2024.01.029چکیده
Curcumin, a naturally occurring polyphenol, has shown promising anti-cancer properties, but its clinical application is hindered by poor bioavailability. Chitosan nanoparticles (CHNPs) have emerged as a potential solution to enhance curcumin delivery due to their biocompatibility, biodegradability, and ability to facilitate targeted drug delivery. This review focuses on the development and application of curcumin-loaded chitosan nanoparticles (Cur-CHNPs) for precision cancer therapy. It highlights recent advances in synthesis methods, characterization, and mechanisms of tumor targeting. Additionally, the review discusses the in vitro and in vivo studies that demonstrate the efficacy of Cur-CHNPs, and explores future directions for improving cancer treatment.
