Investigation on the Possible Cutaneous Toxicity of Silver Nanoparticles in Swiss Albino Rats
نویسندگان
1 College of Medical Techology, Al-Farahidi University, Iraq
2 Department of Dentistry, AlNoor University College, Bartella, Iraq
3 Mazaya University College, Iraq
4 College of MLT, Ahl Al Bayt University, Kerbala, Iraq
5 Medical Laboratory Techniques Department, Al-Mustaqbal University College, 51001 Hillah, Babylon, Iraq
6 Department of Prosthetic Dental Technology, Hilla University College, Babylon, Iraq
doi
10.22052/JNS.2022.03.028چکیده
Due of its potent antibacterial effect, nanosilver is among the most commonly used nanomaterials. As a result of this, there is a growing concern regarding the potential adverse effects of these nanoparticles due to the rising likelihood that humans may be exposed to nanosilver. In this research, we studied the possible cutaneous toxicity of silver nanoparticles in rats. The statistical population of this study consisted of 30 adult male Swiss albino rats (100-150g). They were acquired from animal farm of the Egyptian Organization for Biological Products and Vaccines (VACSERA Holding Company), Cairo, Egypt. For this experiment, they were split into the treatment and control groups (n = 15) at random. Anesthetics were administered to all animals, and the backs were shaved around the spinal column in the nanosilver group and the control group, respectively. The sterile bandages of rats were then moistened with distilled water (in control) or a volume of 55µl of 15µg/ml of nanosilver solution (in treatment) before being adhered to the skin with cloth glue. The bandages were removed after 4 and 8 days, and standard kits were used to determine the serum levels of two groups of rats’ aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine (Cr), and blood urea nitrogen (BUN). BUN, AST, and ALT levels in the treatment group over the experiment periods were significantly higher than those in the control group (p<0.05). According to the results of this study, 15µg/ml nanosilver (45nm) absorbed through the skin can cause renal toxicity and hepatotoxicity in rats.
