Synthesis of NiO Nanoparticles and Sulfur, and Nitrogen co Doped-Graphene Quantum Dots/ NiO Nanocomposites for Antibacterial Application
نویسندگان
1 Food Science Department-Agriculture College-Basrah University, Basrah 00964, Iraq
2 Department of regulatory affairs in the sphere of drugs products and medical devices, Medical University of the Ministry of Health of the Russian Federation
3 Department of Pharmacology, saveetha dental College and hospital, saveetha institute of medical and technical sciences,chennai, india
4 Department of Humanities and Socio-Economic Disciplines Associate Professor, K G Razumovsky Moscow State University of technologies and management, Moscow, Russian Federation
5 Department of Pharmacology, saveetha dental College and hospital, saveetha institute of medical and technical sciences,chennai, india
6 Department of theory and history of state and law, Southwest State University, Kursk, Russian Federation
7 Department of Industrial electronics and lighting engineering, Kazan State Power Engineering University, Russian Federation
doi
10.22052/JNS.2021.01.019چکیده
The human life is faced with bacterial infections which are one of the major cause of prevalence and mortality. Antibiotics have long been the preferred therapy for bacterial infections due to their cost-effectiveness and efficacy. In the field of overcoming microbial issues, new and emerging nanostructure-based materials have gotten a lot of attention. In this Study, NiO and sulfur, and nitrogen co doped-graphene quantum dots-decorated NiO nanocomposites (S,N-GQDs/NiO) are prepared via a simple hydrothermal method. Structural and morphological properties of products are determined via XRD, SEM, UV-Vis, and FTIR analysis. The prepared products are applied for the investigation of antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and methicillin resistant Staphylococcus aureus (MRSA). The results showed that prepared S,N-GQDs/NiO nanocomposites have high antibacterial activity against Staphylococcus aureus among a wide range of microorganisms. For S,N-GQDs/NiO nanocomposites nanoparticles, the disk diffusion test proved that the highest growth inhibition zone was related to Staphylococcus aureus (17 mm). The presence of graphene quantum dots in S,N-GQDs/NiO nanocomposites facilitates reactive oxygen species (ROS) mechanism which lead to bet antibacterial activity.
