Histomorphometrical evaluation of the gastrointestinal mucosa following chronic administration of Ghrelin in rat

نویسندگان
Kheradmand, Arash ID 1
Sheikhzadeh, Farzam ID 2
Zendehdel, Morteza ID 3
زنده دل, مرتضی ID 4
Taati, Majid ID 5

1 گروه پاتوبیولوژی، دانشکده دامپزشکی دانشگاه لرستان، خرم آباد

2 گروه زیست شناسی جانوری، دانشکده علوم طبیعی دانشگاه تبریز، تبریز

3 گروه علوم پایه، دانشکده دامپزشکی دانشگاه تهران

4 گروه زیست شناسی جانوری، دانشکده علوم طبیعی دانشگاه تبریز، تبریز

5 گروه پاتوبیولوژی، دانشکده دامپزشکی دانشگاه لرستان، خرم آباد

doi
10.22059/ijvm.2011.23845
چکیده

Ghrelin, a peptide hormone, has several functions, of which the best known is its growth hormone (GH)-releasing effect in the pituitary. It also increases appetite and feeding behavior. Recent studies have implicated ghrelin in the regulation of gastrointestinal, cardiovascular, and immune function, and suggest a role for ghrelin in bone physiology. In this study, the effect of chronically administered ghrelin on the histomorphometrical properties of stomach and different parts of intestinal mucosa were evaluated in a rat model. Significant differences between control and ghrelin-treated groups were observed in gastrointestinal mucosa, stomach gland length, and duodenal mucosal thickness, villus length and crypt depth (P

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