Evaluation of Biological Activity of 5-Fluoro-Isatin Thiosemicarbazone Derivatives
نویسندگان
1 Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Kastamonu University
2 Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Kastamonu University
3 Department of Biomedical Engineering, Faculty of Engineering and Architecture, Kastamonu University
4 Department of Medical Sciences, Faculty of Medicine, Kutahya University of Health Sciences
5 Sen Research Group, Department of Biochemistry, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus, 43100 Kütahya, Turkey
6 Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Kastamonu University
7 en Research Group, Department of Biochemistry, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus, 43100 Kütahya, Turkey
8 en Research Group, Department of Biochemistry, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus, 43100 Kütahya, Turkey
9 Department of Infectious Diseases, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey
doi
10.22052/JNS.2020.03.007چکیده
Isatin based materials can exhibit a wide range of biological activities including antimicrobial, antiviral, antifungal, anthelmintic, antitumor, anti-HIV, anti-inflammatory, antidepressant, antioxidant, anticonvulsant, antitubercular, analgesic, and central nervous system depressant activities. In this study, four compounds containing 5-Fluoro-isatin thiosemicarbazone with methoxyphenyl or methoxyphenyl in different positions and zinc complexes were evaluated based on their biological activities. Compound 2 was the strongest compound affecting gram-negative bacteria compared to the other compounds. Also, this compound indicated better antimicrobial activity than positive control antibiotics. Besides, compound 3 was the only compound that inhibited the growth of Salmonella spp. such as Salmonella enteritidis ATCC 13076 and Salmonella typhimurium NRRLE 4463. 5-Fluoro-Isatin thiosemicarbazone and its derivatives also showed DNA protection property from moderate to good protections. Among them, compound 4 displayed the highest DNA binding affinity. These compounds possessed a capacity for utilization as drugs or drug additives based on their effects on bacteria strains and DNA binding affinity.
