فهرست نشریات علمی دسترسی آزاد ایران

The effects of three Ficus carica leaf extracts on the total cholesterol levels (TC) of serum and liver were investigated in experimentally-induced nutritional hyperlipidemic rats. In nine treatment groups (n=5 each group), hyperlipidemic rats were treated daily with hydromethanolic (total) extract (2.5, 5, 10 mg/kg, intraperitoneal [ip]) and its aqueous fractions, namely fraction A (10, 50, 250 mg/kg, ip) and fraction B (10, 50, 250 mg/kg, ip) for eight days. In negative and positive control groups, animals received normal and hyperlipidemic diets with ip injections of normal saline, respectively. The lipid-lowering effect of total extract on liver cholesterol was more pronounced than that of serum. Fraction A caused a significant dose-dependent decrease in cholesterol levels in both the serum and the liver (p