Coal Tar Pitch / Graphene / Polyglycine Modified Pencil Graphite Electrode for Simultaneous Electrochemical Detection of Guanine and Adenine
نویسندگان
1 Chemistry Department, Institute of Science, Necmettin Erbakan University, Konya, Turkey
2 Chemistry Department, Ahmet Keleşoğlu education Faculty, Necmettin Erbakan University, Konya, Turkey
3 Chemistry Department, Institute of Science, Necmettin Erbakan University, Konya, Turkey
4 Chemistry Department, Ahmet Keleşoğlu education Faculty, Necmettin Erbakan University, Konya, Turkey
5 Chemistry Department, Science and Art Faculty, Dumlupınar University, Kütahya, Turkey
6 Chemistry Department, Ahmet Keleşoğlu education Faculty, Necmettin Erbakan University, Konya, Turkey
doi
10.22034/ijnn.2025.2014213.2446چکیده
In this study, a coal tar pitch / graphene / polyglycine modified pencil graphite electrode sensor was developed for the quantitative detection of guanine and adenine, two of the most important components of DNA and RNA. Therefore, the determination of guanine and adenine is of great significance. The coal tar pitch / graphene / polyglycine modified pencil graphite electrode was characterized by scanning electron microscope. Cyclic voltammetry, electrochemical impedance spectroscopy, linear sweep voltammetry, and square wave voltammetry techniques were employed to analyze the behavior of guanine and adenine on coal tar pitch/ graphene/ polyglycine modified pencil graphite electrode in 0.1 M of H2SO4. Under the optimal conditions, electrical signals were linear over the concentration ranges from 1.0 to 25 μM and 10.0 to 140 μM for simultaneous determination of guanine and adenine with the detection limit as low as 0.6 μM and 6 μM, respectively. As a candidate for developing electrochemical sensors, the coal tar pitch/ graphene/ polyglycine modified pencil graphite electrode sensor presented here has a wide range of potential applications.
