Screening Assessment of the Potential Hazard of Nanomaterials using a Bull Sperm
نویسندگان
1 Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine
2 State Institution «Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine», Kyiv, Ukraine
3 State Institution «Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine», Kyiv, Ukraine
4 State Institution «Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine», Kyiv, Ukraine
5 State Institution «Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine», Kyiv, Ukraine
6 State Institution «Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine», Kyiv, Ukraine
7 Bogomolets National Medical University, Kyiv, Ukraine
8 Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
doi
10.22034/ijnn.2023.557252.2236چکیده
This paper studied a potential hazard of titanium dioxide nanomaterials in the primary sreening methods on the sample of bull sperm. A method for stabilizing metal nanopowders and their derivatives for biomedical studies is proposed. It was found that the complex of titanium dioxide doped with silver (Ag-TiO2) and nanopowder of titanium dioxide (TiO2) at concentrations of 3 mg/ml initiate pathological changes in the bull sperm: the release of phospholipids as a result of the destruction of membranes and morphological abnormalities (abnormalities of the head, middle part, and tail, as well as the absence of acrosome, etc). The pathological effect of Ag-TiO2 nanocomposite was more pronounced. Doping with silver can increase the toxicity of nanotitanium dioxide, which requires further in-depth experimental studies using different concentrations by in vivo and in vitro methods.
