Fabrication of PGS/CaTiO3 Nano-Composite for Biomedical Application
نویسندگان
1 Biomaterial Engineering group, Isfahan University of medical sciences, Isfahan, Iran
2 Department of Nanotechnology Engineering, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan 81746-73441, Iran
3 Biomaterial Engineering group, Isfahan University of medical sciences, Isfahan, Iran
doi
چکیده
Biodegradable elastomeric materials are gaining extensive attention in the field of soft tissue engineering. Poly (glycerol sebacate) (PGS) is a novel biocompatible elastomer in this scope. However this polymer has poor mechanical properties especially when the molar ratio of glycerol is higher than sebacic acid. Calcium Titanate (CaTiO3) is a biocompatible ceramic with some degrees of piezoelectricity, which is in favor of cell growth. In this study; Calcium Titanate is synthesized at nano-scale by sol-gel method and dispersed into as-synthesized PGS pre-polymer in weight-ratio of 5:95 for CaTiO3 and PGS, respectively. This waxy material was cured to achieve the final product. The molar ratio of glycerol and sebacic acid for the synthesis of PGS was 1:0.8, respectively. X-ray diffraction (XRD) test confirms successful synthesis of CaTiO3 and the nano-scale of crystals are approved by transmission electron microscopy (TEM) Image. Fourier transform infrared (FTIR) spectroscopy has revealed a chemical bond between the two phases after addition of ceramic into pre-polymer. Distribution of CaTiO3 nano-structures in the polymeric matrix is shown by Scanning Electron Microscopy (SEM).
