فهرست نشریات علمی دسترسی آزاد ایران

Background and Objectives: Deficiency of study report the prognosis and laboratory indices of hematological malignancy (HM) patients infected with Omicron-associated pneumonia. We conduct this study to compare HM patients infected with Omicron-associated pneumonia and non-hematological malignancy (NHM) patients, to discuss the prognosis of HM patients infected with Omicron-associated pneumonia and characterize their laboratory indices.    Methods: We collected information from 41 HM and 125 NHM patients infected with the Omicron-associated pneumonia in The First Affiliated Hospital of Chongqing Medical University (Chongqing, China) to analyze. Binary logistic regression analysis and Nonparametric test was used to characterize the prognosis and laboratory indices, and propensity-score matching was used to adjust the influence of confounding factors.    Results: In no need to inhale oxygen/routine oxygen inhalation patients, HM patients had the higher rate of 14-days in hospital than NHM patients (Multivariable propensity-score analysis, OR=13.00, 95%CI=1.97-86.04; P=0.008). The outcomes of laboratory indices showed most patients’ lymphocytes are lower than standard value, level of PCT, CRP and IL-6 are higher than standard value. Comparing with NHM patients, HM patients had the higher level of PCT and IL-6 at the beginning of hospitalization. The number of lymphocytes in HM patients increased after treatment (Mean of difference (After-before) =1.17, 95%CI=0.04-2.30, P=0.044).    Conclusion: Comparing with NHM patients, HM patients had the longer hospitalization time, and had the higher level of PCT and IL-6 at the beginning of hospitalization. For HM patients, the number of lymphocytes is lower than standard value at the beginning of hospitalization, but increased after treatment.