فهرست نشریات علمی دسترسی آزاد ایران

Background and Objectives: Iliac vein compression syndrome is a peripheral venous disease that has attracted much attention in recent years. Severe iliac vein compression syndrome can lead to secondary deep vein thrombosis, aggravate chronic venous insufficiency of lower limbs, and lead to pain, swelling and other symptoms of affected limbs, which can be life-threatening if not treated in time. It aimed to assess the outcome of endovascular intervention (EVI) on the levels of inflammatory factors in patients with May-Thurner syndrome (MTS) complicated with acute left lower extremity deep vein thrombosis (LEDVT).Methods: The medical records of 180 MTS subjects with acute left LEDVT undergoing EVI in Chongqing Dongnan Hospital from October 2020 to March 2024 were collected for research. All subjects were tested for blood routine, coagulation function, and inflammatory factors before and following remedy.Results:Following remedy, the levels of inflammatory factors C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), IL-6, and IL-10 were markedly decreased as against those before remedy (P<0.05). Moreover, the decrease of CRP level was positively correlated with the improvement of D-Dimer (D-D) and fibrinogen (FIB) levels. Only 8.33% of patients recurred within one year after operation, and the venous patency and Villalta score were markedly stable at 3 and 12 months after operation.Conclusion:This article shows that EVI can not only directly relieve vascular compression, but also positively affect the disease process by regulating the inflammatory response. It provides a scientific basis for the application of EVI in such diseases.