فهرست نشریات علمی دسترسی آزاد ایران

   Background and Objectives: Idiopathic Thrombocytopenic Purpura (ITP) is an acquired disorder characterized by isolated thrombocytopenia with otherwise normal CBC and peripheral smear. This study aimed to determine the frequency of splenomegaly and anemia among hospitalized patients with confirmed ITP.    Methods: This descriptive-analytical cross-sectional study was conducted in 2024, utilizing five years of hospital records, and included 150 adult patients with a final diagnosis of ITP. Statistical analysis was performed using STATA 14, applying descriptive statistics, chi-square or Fisher’s exact tests, and logistic regression, with a significance level of P < 0.05.   Results: Our study included 150 patients with a mean age of 38.0 ± 13.5 years, comprising 87 females (58.0%) and 63 males (42.0%). The prevalence of splenomegaly was 8%, anemia was 46.7 %, and the prevalence of concurrent splenomegaly and anemia was 4%. Anemia was present in 41.3% of males and 50.6% of females, and splenomegaly was present in 14.29% of males and 3.45% of females. Gender and hospital stay were significantly associated with splenomegaly (male gender: OR = 6.452, 95% CI: 1.18–35.17, P = 0.031; hospital stay: OR = 1.254, 95% CI: 1.02–1.53, P = 0.028).    Conclusion: The prevalence of splenomegaly was 8%, which is lower than reported in many studies, while anaemia occurred in 46.7%, consistent with previous findings. No significant association was observed between splenomegaly and anemia, though studies differ on this relationship. Further research is recommended.