فهرست نشریات علمی دسترسی آزاد ایران

Background: To evaluate the predictive performance of the new, race-neutral 2021 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimating glomerular filtration rate (eGFR) in forecasting acute kidney injury (AKI) and 90-day all-cause mortality following coronary artery bypass grafting (CABG).  Methods: This retrospective cohort study utilized data from the MIMIC-IV database, including 2,214 adult patients undergoing their first CABG. Postoperative eGFR was calculated using the CKD-EPI 2021, CKD-EPI 2009, and MDRD equations. LASSO and multivariable logistic regression analyses were performed to identify independent predictors for postoperative AKI (primary outcome) and 90-day mortality (secondary outcome). The predictive accuracy of the models was assessed using the area under the receiver operating characteristic curve (AUC).  Results: Postoperative AKI occurred in 365 patients (16.5%), and 48 patients (2.2%) died within 90 days. Postoperative eGFR calculated by the CKD-EPI 2021 equation was an independent predictor for both AKI (OR: 0.99, 95% CI: 0.99–1.00) and 90-day mortality (OR: 0.96, 95% CI: 0.95–0.97). The AUC for the CKD-EPI 2021 equation was 0.64 for predicting AKI and 0.80 for predicting 90-day mortality. Its predictive performance for both outcomes was comparable to the CKD-EPI 2009 equation.  Conclusion: Our results suggested that the race-neutral CKD-EPI 2021 equation seems to be a valid independent predictor of both AKI and short-term mortality after CABG. Its prognostic performance was comparable to the CKD-EPI 2009 formula, supporting its clinical utility for risk stratification in this patient population.