فهرست نشریات علمی دسترسی آزاد ایران

 Background and Objectives: Gastrointestinal stromal tumors (GIST) are a rare group of tumors occur from the mesenchymal tissue of the gastrointestinal tract. Many classifications have been developed to assess the survival of GISTs. Aim of this study is to evaluate the effects of tumor characteristics and existing classification systems on survival in GISTs.    Methods: Study was conducted as a single center retrospective cohort study. We evaluated pathology results and the medical records of patients who had surgery for GIST at Tepecik Training and Research Hospital between 2010 and 2020 retrospectively.   Results: A total of sixty-eight patients were detected. Thirty-three (48.5%) of the patients were male and the mean age at initial diagnosis was 60.8±11.9 years. Thirty-seven (54.4%) of the primary tumor was localized in the stomach and the median tumor size was 6.8 cm. Mortality rate was higher in patients with irregular tumor contour (P=0.044). Mortality rate was higher in patients with colonic GIST (P=0.026). Armed Forces Institute of Pathology (AFIP) was found as the best classification system that could assess the prognosis (AUC:0.758 (0.644-0.872), P=0.001). Among various factors, only the mitotic index was found as a risk factor in the development of recurrence (HR (95%CI): 1.019 (1.006-1.032), P=0.004).     Conclusion: The best prognostic factor for disease-free survival in GISTs is the mitotic index. In addition, Ki-67 index, tumor size, presence of necrosis and hemorrhage should be considered as other factors that may be related to disease-free survival. Colorectal GISTs have the worst postoperative mortality and recurrence rates.