Vitamin E Serum Levels in Patients with Breast Cancer in North of Iran
نویسندگان
1 Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
2 General practitioner, Sari, Iran
3 Cellular and Molecular Research Center, Mazandaran University of Medical Sciences, Sari, Iran
4 Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
5 Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
6 Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
7 Population-Based Cancer Registry, Mazandaran University of Medical Sciences, Sari, Iran
8 Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
doi
10.22034/ircmj.2025.496742.1755چکیده
Background and Objectives: Breast cancer is among the most prevalent cancers in women, ranking as the second cause of women’s death from cancer after lung cancer. Known as the most important lipophilic antioxidant, vitamin E plays a key role in preventing cancer. This study aims to analyze the serum levels of vitamin E and its effects on breast cancer. Methods: In this case–control study, 42 women with breast cancer were compared with 50 healthy women. The enzyme-linked immunosorbent assay (ELISA) test with a ZellBio kit (made in Germany) was employed to measure the serum levels of vitamin E. The T-test, Anova, and Pearson correlation were used in SPSS 26 to determine the significant differences of data. Results: The mean age (± standard deviation) of the case group was 46.9 (± 7.01), whereas that of the control group was 40.8 (± 4.7) with a significant difference (P=0.000). Moreover, the mean vitamin E serum level of the case group was significantly lower than that of the control group (P=0.002). The findings also indicated that the serum level of vitamin E had no significant association with the cancer stage, cancer grade, tumor size, estrogen status, progesterone status, and HER2. Conclusion: The serum levels of vitamin E are lower in patients with breast cancer than in a healthy population.
